The investigators previously demonstrated that epidural ropivacaine reduces uterine artery vascular resistance in a dose dependent manner in pre-eclampsia. The investigators also noted a marked right-left difference in vascular resistance between paired uterine arteries, which was almost completely abolished following epidural ropivacaine. However, this novel observation was not a stated outcome variable before the study began. This study assesses right-left difference in vascular resistance between paired uterine arteries as a primary end-point, assesses the dose-response effect of epidural lidocaine and compares the effect observed in pre-eclampsia with that in two control populations (term normal pregnancy and non-pregnant controls).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Epidural 2% lidocaine, administered in 5mL incremental boluses. Looking at dose-response effect.
5 x 5ml boluses of either epidural lidocaine 2% or epidural saline
Hadassah Hebrew University Medical Center
Jerusalem, Israel
Uterine artery pulsatility index (by Doppler ultrasound). Specifically the right-left uterine artery difference.
Time frame: 15min after each dose - on a dose--response curve
Uterine artery pulsatility index (worse vessel)
Time frame: 15 min after dose
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.