The study will evaluate the safety, tolerability and immunogenicity of different doses and types of Influenza Vaccine in healthy elderly subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
450
1 dose of Trivalent Influenza Vaccine
1 dose of Trivalent Influenza Vaccine with high A content
1 dose of Trivalent Influenza Vaccine plus ¼ dose adjuvant
Center For Vaccinology
Ghent, Belgium
Assessment of all adverse events from time of vaccination through study end will be collected to for safety assessment.
Time frame: 21 days
Strain-specific influenza antibody titers will be used to assess Immunogenicity
Time frame: 21 days
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1 dose of Trivalent Influenza Vaccine with high A plus ¼ dose adjuvant
1 dose of Trivalent Influenza Vaccine plus ½ dose adjuvant
1 dose of Trivalent Influenza Vaccine with high A plus ½ dose adjuvant
1 dose of Trivalent Influenza Vaccine plus adjuvant
1 dose of Trivalent Influenza Vaccine with high A plus adjuvant
1 dose of Trivalent Influenza Vaccine intradermal dose
1 intradermal dose of Trivalent Influenza Vaccine + high A