Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate

University of Mississippi Medical Center1 enrolled

Overview

The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertension

Interventions

MetoprololDRUG

Metoprolol tablets 25-200 mg daily times four weeks. Nebivolol daily for 4-5 weeks

NebivololDRUG

5 - 20 mg daily, at a stable dose for 4 to 5 weeks

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years old or older * currently be treated at a University of MS Medical Center Internal Medicine Clinics * currently taking metoprolol succinate for hypertension * have their hypertension controlled (\<140/90). Exclusion Criteria: * uncontrolled hypertension * severe renal or moderate hepatic impairment * currently taking CYP 2D6 inducers/inhibitors * recent stroke (less than 6 months) * recent myocardial infarction (less than 6 months) * congestive heart failure * diagnosed obstructive sleep apnea * atrial fibrillation * arm circumference \>50 cm

Locations (1)

University of Mississippi Medical Center

Jackson, Mississippi, United States

Outcomes

Primary Outcomes

Primary Outcome is Pre- and Post-treatment Ambulatory Blood Pressure.

Time frame: 4 weeks (pre- and post-treatment)

Data from ClinicalTrials.gov

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