The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.
3 treatment plans will be created to deliver between a total of 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV). 1. Proton Plan 2. Conventional Plan 3. Intensity Modulated Radiotherapy (IMRT) Plan The patient will then receive the radiation modality with the lowest percentage of the body receiving 4 Gy (V4Gy/CGE)
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Between 21-39.6 Gy/CGE to the PTV
Between 21-39.6 Gy/CGE to the PTV
Between 21-39.6 Gy/CGE to the PTV
University of Florida Proton Therapy Institute
Jacksonville, Florida, United States
Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.
Time frame: Immediately proceeding completion of each of the three treatment plans
Percentage of Participants Who Survived
Overall survival as assessed with the Kaplan-Meier product limit method.
Time frame: 4 years after beginning of radiation therapy
Percentage of Participants Who Did Not Have Disease Progression
Disease free survival as assessed with the Kaplan-Meier product limit method
Time frame: 4 years after beginning of radiation therapy
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