Vitamin D Deficiency in Obese Adolescent Girls and Influence of Vitamin D on Insulin Secretion and Sensitivity

University of Alabama at Birmingham114 enrolled

Overview

Sub-clinical vitamin D deficiency is a commonly unrecognized disorder in obese adolescents. The investigators hypothesize vitamin D deficiency will be highly prevalent in obese adolescents and those who are vitamin D deficient will be more insulin resistant.

This is a cross-sectional study of obese female adolescents matched for age, sex and pubertal staging. Serum 25-OH vitamin D, intact PTH , lipid profile, serum CRP measurements and oral glucose tolerance tests (with glucose and insulin level measurements) will be done to assess the prevalence of vitamin D deficiency and to assess the insulin sensitivity- resistance indices.

Study Type

OBSERVATIONAL

Enrollment

114

Conditions

Vitamin D Deficiency Obesity Insulin Resistance

Eligibility

Sex: FEMALEMin age: 10 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female adolescents * Obese: BMI \> 95th percentile * Menarchal * Tanner stage ≥ 4 Exclusion Criteria: * Children with diabetes, other endocrine or acute or chronic medical illnesses, children on oral contraceptive pills, diuretics and anticonvulsant medications

Locations (1)

Children's Hospital, Universiy of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

To determine the prevalence of subclinical vitamin D deficiency in obese female adolescents.

Time frame: At study entry

Secondary Outcomes

To assess the relationship of serum 25 (OH) D statuses to insulin and glucose concentrations during an OGTT and to serum transaminases and CRP.

Time frame: At study entry

Data from ClinicalTrials.gov

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