Ovarian cancer patients are often at risk of malnutrition because of weight loss, lack of appetite and reduced food intake. Being malnourished can contribute to the incidence and severity of cancer treatment side effects and increase the risk of infection. Currently patients with advanced ovarian cancer do not receive early nutrition using a feeding tube. The purpose of this study is to compare enteral nutrition along with standard post-surgery care against current standard post-operative care alone. This study will see if early nutrition using a feeding tube has an impact on length of hospital admission, recovery from surgery, complications from surgery, nutritional status and ultimately a reduction in treatment costs in people with Advanced Epithelial Ovarian Cancer (EOC). Primary Peritoneal Cancer (PPC) or Fallopian Tube Cancer. Nutritional support has been shown to ; * Prevent and treat under-nutrition, * Enhance anti-tumour treatment effects, * Reduce adverse effects of anti-tumour therapies, * Improve quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
109
During primary surgical treatment an enteral feeding tube will be inserted through the patient's nose into their small bowel. Enteral feeding will commence 4 hours following return to ward from surgery. Feeding will start at a rate of 40 ml/hr for the first 24 hours, and then increased to goal weight. Goal will be calculated by 125 kiloJoules/kilogram adjusted body weight.
The Wesley Hospital
Auchenflower, Queensland, Australia
Brisbane Private Hospital
Brisbane, Queensland, Australia
Greenslopes Private Hospital
Greenslopes, Queensland, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia
Mater Health Services
South Brisbane, Queensland, Australia
Gold Coast Hospital
Southport, Queensland, Australia
Cost outcomes as represented by length of stay and cost effectiveness of enteral feeding / Quality of life
Compare treatment costs and cost effectiveness between early enteral feeding with standard post-operative care versus current standard ost-operative care for advanced epithelial ovarian cancer. Compare quality of life after surgery between women who receive early enteral feeding along with standard post-operative care versus those who receive current standard post-operative care for advanced epithelial ovarian cancer
Time frame: End of study
length of stay
Length of stay in an intensive care unit or high dependency unit and overall length of hospital stay.
Time frame: Until discharge from hospital
Need for inotropic medications and intravenous treatment requirements
Time frame: Until discharge from hospital
Nutritional status 6 weeks after surgery
Time frame: 6 weeks after surgery
Treatment related adverse events
Time frame: End of study
Delay and dose reductions of chemotherapy / quality of life during chemotherapy
Time frame: End of study
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