Impact of N-Acetylcysteine on Oxidative Stress and Renal Function in Deceased Kidney Transplant Recipients

University of Sao Paulo

Overview

The aim of this interventional, prospective, randomized clinical trial is to evaluate the impact of the antioxidant N-acetylcysteine on oxidative stress in the first seven postoperative days and on renal function in the first three postoperative months in deceased kidney transplantation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Conditions

Deceased Kidney Transplantation

Interventions

N-acetylcysteineDRUG

600 mg bid orally from day 1 to 7 postoperative

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * First transplant * Deceased kidney transplant Exclusion Criteria: * postoperative recovery at critical care unit * illicit drug addiction * psychiatric disorders

Locations (1)

Clinics Hospital, University of Sao Paulo, Medical School

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Tiobarbituric acid reactive species measures

Time frame: First seven postoperative days

Secondary Outcomes

Serum creatinine

Time frame: 7, 15, 30, 60, 90 postoperative day

Data from ClinicalTrials.gov

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