Study of EC0489 for the Treatment of Refractory or Metastatic Tumors

Inclusion Criteria: * 18 years of age or older * Histological or cytological diagnosis of neoplasm * No effective standard therapeutic options * ECOG performance status of 0-2 * ≥ 4 weeks post therapeutic radiation or recovered (or returned to baseline) from any acute toxicity associated with prior cytotoxic therapy. Patients previously treated with non-cytotoxic therapy (e.g., EGFR, VGEF, etc.) and who have recovered from or have controlled drug-associated toxicity are allowed to enter the trial after a period consisting of 4 half-lives of the agent. * Negative serum pregnancy test for women of child-bearing potential within one week prior to treatment with investigational agents (99mTc-EC20 and EC0489)and willingness to practice contraceptive methods * Adequate bone marrow reserve, renal and hepatic function Exclusion Criteria: * Concurrent malignancies * Women who are pregnant or breast-feeding * Evidence of symptomatic brain metastases * Receiving concomitant anticancer therapy (excluding supportive care) * Requires palliative radiotherapy at time of study entry * Requires antifolate therapy for comorbid conditions * Heart failure characterized as greater than NYHA Class I * History of myocardial infarct * Any of the following baseline echocardiogram findings: valvular lesions (stenosis or insufficiency) characterized as greater than moderate, systolic ventricular impairment characterized as greater than mild, left ventricular ejection fraction \< 55%, any feature of the echocardiogram that would confound interpretation of the serial echocardiograms required by the protocol