The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery

University of Toronto140 enrolled

Overview

Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

140

Conditions

Chronic Sinusitis

Interventions

1% lidocaine with 1:100,000 adrenalineDRUG

high dose

1% lidocaine with 1:200,000 adrenalineDRUG

1% lidocaine with 1:200,000 adrenaline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * recurrent acute sinusitis, chronic sinusitis, or nasal polyposis Exclusion Criteria: * bleeding disorders, under age of 18, history of cardiac disease or on antihypertensive medications

Locations (1)

University of Toronto

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Reduction of Intraoperative bleeding

Time frame: during surgery

Secondary Outcomes

hemodynamic fluctuation

Time frame: during surgery

Central Contacts

Ali Moshaver, MD

CONTACT

250-276-5050 moshaver@yahoo.com

Data from ClinicalTrials.gov

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