Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment

Technische Universität Dresden86 enrolled

Overview

Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation. The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Acute Lung Injury

Interventions

Intermittent Non-Invasive Ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: patients undergoing allogeneic transplantation presenting with at least two of the following criteria * Respiratory rate \>25 / min * Oxygenation Index \<300 * Continuous oxygen-saturation \<92% whilst breathing room air Exclusion Criteria: * Indication for Emergency intubation * Hemodynamic instability * Left ventricular failure * GCS \<8 * No consent