Sedation and Pain (The Effect of IV Sedation on Pain Perception)

University of Alabama at Birmingham86 enrolled

Overview

The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).

We propose to contrast and compare the effect of propofol and midazolam, two GABA-related sedative drugs, and dexmedetomidine, an alpha-2 adrenergic agonist, on pain perception in human volunteers by asking a participant to rate their pain and by evaluating a subject's brain activation using fMRI.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Pain

Interventions

dexmedetomidineDRUG

midazolamDRUG

propofolDRUG

Eligibility

Sex: ALLMin age: 19 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Healthy subjects * 19 years or older able to follow study instructions Exclusion Criteria: * Age less than 19 or greater than 40 * Pregnant female * Obesity (BMI \> or =35) * Non-English speaking/reading participants * Sleep apnea * Pulmonary problems such as moderate or severe bronchial asthma * Cardiovascular problems such as hypertension * History of claustrophobia * Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device * Presence of an unremoved bullet or shrapnel in the body * Presence of a prosthetic that is not removable * Presence of a hearing aid needed for hearing * Head girth exceeding that of the head coil used in the magnet * Extensive metalwork on or in teeth, or irremovable false teeth or bridgework * Epilepsy * Chronic analgesic medication * Excessive tattoos (due to local skin heating with tattoos containing ferromagnetic particles) * History of surgery for which details are unavailable * Allery due to study drugs * History of drug abuse

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

Pain Rating Change

Mechanical Slide Algometer (www.decisionaidsonline.com), Range: "No Pain Sensation" (1) to " Most Intense Sensation Imaginable" (10) 10 point scale. Change Time Points: Baseline (no sedation), Sedation. Same Day Intervention.

Time frame: Sedation

Data from ClinicalTrials.gov

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