Psychosocial Treatment of Depression in Parkinson's Disease

Inclusion Criteria: In addition to the DSM-IV diagnostic criteria for major depressive disorder, the following conditions must be met for patient eligibility: * Written informed consent. * Subjects with a primary diagnosis of PD who also currently meet DSM-IV criteria for MDD * Subjects must be stable on their anti-Parkinson treatment, as defined by no medication changes over the past 6 weeks * Subjects may be taking an antidepressant as long as they have had a stable dose for up to 6 weeks and do not alter the dosage during the course of the study * Men or women 40-80 years of age * HAMD-17 scores \> 14 at screen visit * Score of 25 or greater on the Mini-Mental Status Examination * Willing to come to MGH for screening and study participation Exclusion Criteria: Patients meeting any of the following criteria are to be excluded from the study: * Subjects who, in the investigator's judgment, pose a current, serious suicidal or homicidal risk * Patients who would not be appropriate for a delayed CBT control due to the severity of their depression based on clinical judgment as well as HAMD-17 scores \> 28 * The following DSM-IV diagnoses: 1) substance use disorders, including alcohol dependence, active within the last 3 months; 2) schizophrenia; 3) delusional disorder; 4) psychotic disorders not elsewhere classified; 5) bipolar disorder; 6) MDD with psychotic features * Subjects who meet DSM-IV criteria for dementia * Severe, unstable concurrent medical conditions (determined by his/her physician) that are likely to require hospitalization within six months from study entry (e.g., a patient with severe congestive heart failure who has a history of recent hospital admissions) * Subjects may not be receiving a psychosocial intervention that is specific for depression; psychosocial interventions not specific for depression (e.g., couples counseling) and established for three or more months before screen visit are allowed