Goal-directed Fluid Resuscitation in Acute Pancreatitis

Brigham and Women's Hospital40 enrolled

Overview

Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.

Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis. Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Pancreatitis

Interventions

Goal-directed fluid resuscitationOTHER

Targeted, weight-based fluid resuscitation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute pancreatitis diagnosed by at least 2 criteria * adult patients at least 18 years of age Exclusion Criteria: * history of severe cardiovascular, respiratory, renal, hepatic or hematologic/immunologic disease * concurrent metabolic or physiologic derangement requiring specific fluid management * pregnancy * patients transferred from acute care hospital

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Prevalence (point prevalence) of the systemic inflammatory response syndrome (SIRS) at 24 hours

Time frame: first 24 hours of hospitalization

Data from ClinicalTrials.gov

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