Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

UPECLIN HC FM Botucatu Unesp26 enrolled

Overview

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Patients in Good Health Types of General Anesthesia DNA Damage

Interventions

Comparison of two anesthetic drugsDRUG

Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in good health American Society of Anesthesia status physical I * elective minor surgery * general anesthesia Exclusion Criteria: * smokers * alcoholics * previous medication or radiation

Locations (1)

Botucatu Medical School, UNESP

Botucatu, São Paulo, Brazil

Outcomes

Primary Outcomes

Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile

Time frame: within 1 day after surgery

Data from ClinicalTrials.gov

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