Puerarin Effects on Alcohol Drinking

Mclean Hospital16 enrolled

Overview

This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking. Hypothesis: Short-term treatment with this compound will reduce alcohol self-administration in a simulated natural settings laboratory.

Participants will have an opportunity to drink up to 6 beers, plus water and juice, during a 90 minute afternoon drinking session in our simulated apartment room laboratory. Drinking sessions will be conducted in the afternoon after participants take puerarin or placebo for 7 days.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Alcohol Abuse

Interventions

Puerarin, PlaceboDRUG

400 mg, three times a day for 7 days

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * moderate to heavy alcohol drinkers (20+ drinks per week) Exclusion Criteria: * alcohol dependence or treatment-seeking drinkers * other drug abuse or dependence * psychiatric disorders

Locations (1)

McLean Hospital, Behavioral Psychopharmacology Research Laboratory

Belmont, Massachusetts, United States

Outcomes

Primary Outcomes

Amount of Alcohol Consumed

Time frame: During a 90 minute drinking session

Data from ClinicalTrials.gov

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