The purpose of this study is to find new blood and urine tests that detect acute kidney injury earlier than our current blood tests in patients receiving a liver transplant.
Patients with end stage liver disease that receive a liver transplant will be studied to determine if novel serum and urine biomarkers (serum cystatin C, urine interleukin-18 \[IL-18\] and urine neutrophil gelatinase associated lipocalin \[NGAL\]) can predict the outcome measures listed above.
Study Type
OBSERVATIONAL
University of Colorado Denver
Aurora, Colorado, United States
University of Washington
Seattle, Washington, United States
Development of acute kidney injury as defined by a 50% increase in serum creatinine
Time frame: Within 2 to 5 days of liver transplant that is sustained for at least 24 hours
Development of severe acute kidney injury, as defined as a doubling of serum creatinine
Time frame: Within 2-5 days of transplant that is sustained for at least 24 hours
The need for renal replacement therapy
Time frame: After liver transplant operation to discharge
All cause mortality
Time frame: After liver transplant operation to discharge
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.