Assessment of Endothelial Vasomotricity After Treatment by Nicotinic Acid in Acute Coronary Syndrome

Inclusion Criteria: * informed consent written of the patient * Acute coronary syndrome going back to less than 7 days by the rise higher than 0.10 in troponin associated at least one in the following elements:(symptoms of myocardiac ischaemia, appearance of pathological waves Q, disturb repolarisation in connection with an ischaemia (known or under shift of the segment ST). * HDL - C lower than 0.4 g/l * FMD \< 7% Exclusion Criteria: * Antecedents of myopathy induced by a statin or severe reaction of over-sensitiveness to an inhibitor of the HMG CoA réductase (statins). * Antecedent of family hypercholesterolemia of homozygote type. * Women pregnant, nursing, likely to be pregnant and not using chemical or mechanical contraception or presenting a positive test of pregnancy blood (b-HCG). * Subjects whose substitute hormonal treatment or oral contraception was initiated in the 3 previous months Visit 0. * Active hepatic pathology or hepatocellular insufficiency (doubly of the gammas WP; TGP \> 3 times the normal) * Renal insufficiency engraves with clearance of creatinin \< 30 ml/min. * LDL\<0.70gr/l, triglycerides ³ 400 Mg dL (4.52 mmol/L), hbA1c \> 8.5%, HDL cholesterol \> 0 40g/l. * Evolutionary cancer * Use of the following concomitant treatments: insulin, nitrated derivatives * Antecedents of alcoholism and/or catch dopes during the last year. * CPK ³ 3 times higher limit of the normal and fraction MB of CPK \< 2 times limit higher of the normal than visit 1. If the CK-MB are not available, one will take into account a value of CPK \> 3 times the limit higher of the normal and cardiac Troponin (I or T) \< 0.10 g/l than visit 1. * Clinical history of permanent systolic hypotension (NOT \< 90 mmHg) or permanent not controlled hypertension (NOT \> 200 mmHg gold PAD \> 110 mmHg). * Coronary bridging in the 3 months before inclusion (V1). * Occurred of fibrillation ventricular, tachycardia ventricular constant (other which RIVETTED), complete and permanent auriculo-ventricular Bloc, which has occurred of auricular fibrillation with a ventricular rate/rhythm not controlled (\> 130 bpm), or ventricular rate/rhythm in the 4 weeks preceding visit 1. * Cerebral vascular accident, severe infection, péricardite acute or any other obviousness of known systemic embolism not controlled * Hypothyroïdie defined by a rate of TSH \> 1,5 times higher limit of the normal * Serious or unstable conditions psychological or medical which according to the opinion of the investigator, would compromise the safety of the patient or his participation in the study. * Participation in another clinical trial (other than registers not raising of a biomedical law of research) with treatment the study or having received a treatment the study in the 4 weeks preceding inclusion in the study. * Patients under supervision or trusteeship or without Social Security cover or impossibility of following the specific procedures of the study.