Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation

Inclusion Criteria: Recipient Day of Transplant * Registered male or female primary heart transplant candidate * ≥18 years old * Signed, written informed consent document and authorization to use and disclose protected health information Donor Hearts * \<60 years old * Mean systolic blood pressure \>60 mmHg at the time of final heart assessment * Satisfactory echocardiography assessment defined as: * Ejection fraction \>40% * Absence of severe segmental wall motion abnormalities * Absence of left ventricular hypertrophy (inter ventricular septum and posterior wall thickness \<1.3 cm) * Absence of valve abnormalities (trace to mild valvular regurgitation is acceptable) Exclusion Criteria: Recipient Day of Transplant * \>4 previous sternotomies * Chronic renal failure as defined by chronic serum creatinine \>3.0 mg/dL for more than 2 weeks and/or requiring hemodialysis (except for hemodialysis or hemofiltration for fluid overload) * Ventilator dependence at the time of transplant * Use of a ventricular assist device for \> 30 days and the presence of any of the following: sepsis, intracranial hemorrhage or heparin induced thrombocytopenia * Panel reactive antibodies \> 40% with a positive prospective cross match and/or virtual cross match * Use of an investigational drug or device, other than OCS, during the study. * Simultaneous transplant of non-heart allograft, except for concurrent kidney transplant Donor Hearts * Abnormal coronary angiogram defined as \>50% stenosis, requiring coronary bypass * Donor-to-recipient body weight ratio of \<0.6 * Inotrope support at time of final heart assessment including, but not limited to: * Dopamine \>10 ug/kg/min * Dobutamine \> 10 ug/kg/min * Milrinone \>0.3 ug/kg/min * Epinephrine \> 0.03 ug/kg/min * Norepinephrine \> 0.03 ug/kg/min * Any bolus dose of the above prior to explants that would result in exceeding the above stated criteria * Presence of any exclusion criterion based on the standard practice of the investigational site