Affective Processing in Depression and Epilepsy

Northwell Health14 enrolled

Overview

The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Symptoms of depression is commonly seen in patients with epilepsy. There are similarities and differences between depressive symptoms in epilepsy when compared with primary depression. Through the use of fMRI (Functional MRI), we hope to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Epilepsy Depression Healthy

Interventions

fMRIOTHER

Subjects will undergo MRI scanning to gather data about cognetive functions.

Hamilton Depression Rating ScaleOTHER

Investigator will evalute the subject during a one on one interview for depression using the Hamilton Depression Rating Scale.

Beck's Depressive InventoryOTHER

Subjects will complete self assessment to evaluate their level of depression.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

For Control Group Inclusion Criteria: * Healthy adults of 18 years of age or older. Exclusion Criteria: * Subject has no history of affective disorders * Subject scores higher than 5 on Hamilton Depression Rating Scale * Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder * Subject is pregnant * Subject is unable to undergo a MRI Epilepsy Only Group Inclusion Criteria: * Subject is at least 18 years of age * Subject has confirmed temporal lobe epilepsy (TLE) Exclusion Criteria: * Subject has a history of depression * Subject scores higher then 5 on Hamilton Depression Rating Scale * Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder * Subject is pregnant * Subject is unable to undergo a MRI Depression Only Group Inclusion Criteria: * Subject is at least 18 years of age * Subject scores between 12 and 18 on Hamilton Depression Rating Scale Exclusion Criteria: * Subject scores higher than 18 on Hamilton Depression Rating Scale * Subject is currently being medicated for depression * Subject has history of major depression or dysthymia * Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder * Subject is pregnant * Subject is unable to undergo a MRI Depression and Epilepsy Group Inclusion Criteria: * Subject has confirmed temporal lobe epilepsy (TLE) * Subject scores between 12 and 18 on Hamilton Depression Rating Scale Exclusion Criteria: * Subject has history of major depression or dysthymia * Subject is currently on medication for depression * Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder * Subject is pregnant * Subject is unable to undergo a MRI

Locations (1)

North Shore LIJ Health System

Manhasset, New York, United States

Data from ClinicalTrials.gov

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