Comparison of Enteral Versus Parenteral Feeding in Healthy Human Subjects

Rutgers, The State University of New Jersey12 enrolled

Overview

Literature suggests that route of feeding and/or certain nutrients may cause alterations in the body's immune cells. Immune cells help protect the body and fight infection/disease. Tube feeding (TF) is a method of delivering nutrition directly to the stomach/intestines via a small tube. The immune system may respond differently when receiving continuous TF as compared to receiving intermittent TF. Heart rate variability (HRV, the intervals between heartbeats) is a measurement of the nervous system's response to a stress/illness. The differences in immune cells and/or HRV may influence how the body reacts to complications such as infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Continuous Tube Feeding for 72 hours

Enteral IntermittentDIETARY_SUPPLEMENT

Intermittent Tube Feedings

Parenteral ContinuousDIETARY_SUPPLEMENT

Parenteral Continuously for 72 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * General good health as demonstrated by medical history, physical\& laboratory tests * Age between 18 and 40 years * Written informed consent prior to the performance of any study related procedures Exclusion Criteria: * History of cancer, rheumatoid arthritis, or immunological, renal, hepatic, endocrine, neurologic, heart disease or hypertension * Any medication taken in past 48 hrs (except birth control) * Recent history of alcohol or drug abuse * Unable to provide written informed consent * Exposure to any experimental agent or procedure within 30 days of study * Pregnant or breast-feeding

Locations (1)

Rutgers-RWJMS

New Brunswick, New Jersey, United States

Outcomes

Primary Outcomes

Route and type of feeding on Immune response

Time frame: Day 1- Day 4

Data from ClinicalTrials.gov

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