Obesity and the Initiation of Knee Osteoarthritis

US Department of Veterans Affairs177 enrolled

Overview

Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.

The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.

Study Type

OBSERVATIONAL

Enrollment

177

Conditions

Obesity

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Adults aged 20-60 who have no history of LE surgery * Healthy adults able to walk 30 minutes * Healthy adults able to have MR Exclusion Criteria: * Adults who have had LE surgery * Adults cannot walk 30 minutes * Adults who cannot tolerate MR * Adults with osteoarthritis

Locations (1)

VA Palo Alto Health Care System

Palo Alto, California, United States

Outcomes

Primary Outcomes

Gait Knee Adduction Moment

Time frame: baseline or first and only visit.

Cartilage Thickness

Medial/lateral thickness ratio

Time frame: baseline or first and only visit.

Data from ClinicalTrials.gov

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