Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation

Inclusion Criteria: * at least 18 and no older than 65 on the day of first dosing * healthy * Quetelet Index (Body Mass Index) of 18 to 30 kg/m2 * In general, results of haematology and chemistry should be within the laboratory's reference ranges. Determinants of renal and hepatic function should be within twice the upper limit of normal range. Exclusion Criteria: * Documented history of sensitivity / idiosyncrasy to medicinal products or excipients * history of smoking within the past year * history of or current abuse of drugs, alcohol and/or solvents * Current use of any (over the counter) medication potentially influencing heme oxygenase or the cardiovascular system * Inability to understand the nature and extent of the trial and the procedures required * Participation to a drug trial within 60 days prior to the first dose * Febrile illness within 3 days before the first dose * Heterozygosity (LS) or homozygosity (LL) with regard to the number of GT repeats in the HO-1 promoter region