Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing

Centre Hospitalier Universitaire Vaudois45 enrolled

Overview

This prospective randomized trial evaluated the impact of autologous keratinocytes suspended in platelet concentrates on healing skin graft donor site wounds. It was hypothesized that the treatment would speed and improve wound healing.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Skin Graft

Interventions

Autologous Platelet Rich PlasmaBIOLOGICAL

Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.

Keratinocyte suspensionBIOLOGICAL

Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.

Standard dressingsOTHER

Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Skin graft donor sites total surface \< 15% BSA * Skin graft donor site size: 0.2mm deep, 30 to 40 cm2 surface area Exclusion Criteria: * Patients treated with immunosuppressors * Patients treated with corticoids * Patients suffering from terminal renal insufficiency * Patients suffering from severe peripheral arteriopathy

Locations (1)

Centre hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Complete Wound Healing

Time required for complete epithelialization in days

Time frame: Post operative day 5 and every other day thereafter

Secondary Outcomes

Pain

Pain evaluated on a Visual Analog Scale (VAS) from 0 (no pain) to 10 (extreme pain), specifically during dressing replacement.

Time frame: Post operative day 5

Data from ClinicalTrials.gov

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