Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

Washington University School of Medicine20 enrolled

Overview

Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

HIV (Human Immunodeficiency Virus)Metabolic Syndrome HIV Infections

Interventions

Dietary InterventionBEHAVIORAL

The nutrition curriculum will involve weekly group and individual sessions. The initial calorie goal will be \~750 kcal below the resting energy equivalent, and adjusted as needed to achieve weight loss targets.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Sedentary * Obese * Have either dyslipidemia (HDL \< 50 or triglycerides \> 150), waist circumference \> 88cm, and impaired glucose tolerance or homeostasis model assessment value of \> 3 * Subjects with HIV-MS must have been receiving HAART for \> 6 months Exclusion Criteria: * Medication changes in the last 3 months * Diabetes mellitus * Medical problems that in the opinion of the principal investigator may interfere with patient safety * Substance abuse

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Effect of weight loss on body composition

Time frame: three months

Effect of weight loss on insulin action

Time frame: three months

Secondary Outcomes

Effect of weight loss on body fat mass

Time frame: three months

Effect of weight loss on adipose tissue distribution

Time frame: three months

Effect of weight loss intrahepatic triglyceride content

Time frame: three months

Effect of weight loss on insulin action adipose tissue

Time frame: three months

Effect of weight loss on insulin action in liver

Time frame: three months

Effect of weight loss on insulin action in skeletal muscle

Time frame: three months

Data from ClinicalTrials.gov

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