A Study of the Pharmacokinetics of Testosterone Metered Dose (MD)-Lotion Formulations

Inclusion Criteria: * Male study participants with a prior documented diagnosis of hypoandrogenism as evidenced by previously documented: Hypothalamic, pituitary or testicular disorder or a Serum testosterone less than or equal to 300 ng/dL * Were receiving, or in the investigator's opinion were eligible to receive treatment for hypoandrogenism * Body Mass Index (BMI) less than 35 kg/m\^2 * Passed the required laboratory and physical screening tests * Haemoglobin levels at screening greater than or equal to 13.0 g/dL * Adequate venous access on left or right arm * Able to communicate with study staff, understand the study information sheet and sign the written Informed Consent forms; willing to follow and comply with study procedures Exclusion Criteria: * Any significant history of allergy and/or sensitivity to the drug products or their excipients, including any history of sensitivity to testosterone and/or sunscreens * Any clinically significant chronic illness or finding on screening physical exam and/or laboratory testing * Chronic skin disorder (e.g. eczema, psoriasis) likely to interfere with transdermal drug absorption * Men with suspected reversible hypoandrogenism (i.e. due to medications, stress) * Any man in whom testosterone therapy is contraindicated, which included those with: * Known or suspected carcinoma (or history of carcinoma) of the prostate or symptoms of benign prostatic hyperplasia and/or symptoms of lower urinary obstruction, * Known or suspected carcinoma (or history of carcinoma) of the breast, * Severe liver damage i.e. cirrhosis, hepatitis or liver tumours, * Active deep vein thrombosis, thromboembolic disorders or a documented history of these conditions, * Significant cerebrovascular or coronary artery disease, * Known or suspected sleep apnoea, * Hematocrit \> 51% * Men with clinically significant prostate exam or clinically significant elevated serum prostate specific antigen (PSA) level, or age adjusted reference range of PSA values. * Current history of drug or alcohol abuse (more than 4 standard drinks per day and/or abnormal liver function tests 3 times the upper limit of the normal range values) * Men taking concomitant medications that affect sex hormone binding globulin (SHBG) or testosterone concentrations or metabolism, or that were cytochrome P450 inducers or inhibitors, anti-coagulants (warfarin), or diabetic medications (insulin), anti-histamines * Men involved in sport in which there was screening for anabolic steroids * Men with uncontrolled diabetes (hemoglobin A1c \[HbA1c\] greater than or equal to 10%) * Men taking any Investigational Product, or who had received an Investigational Product within 28 days prior to screening or 5 half-lives (whichever was the longer) * Any contraindication to blood sampling * Study participants who planned to have a surgical procedure during the course of the study * Study participants with a partner of child bearing potential who was not willing to use adequate contraception (i.e. condoms) for the duration of the study * Study participants whose partners were pregnant