The purpose of this study is to characterize the safety and efficacy of STA-9090 (ganetespib) in subjects with hematologic malignancies.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
31
Chemotherapy agent
Unnamed facility
Boston, Massachusetts, United States
Unnamed facility
New York, New York, United States
Unnamed facility
San Antonio, Texas, United States
To characterize the safety and tolerability of STA-9090 (ganetespib) in subjects with hematologic malignancies
Time frame: Feb 2011
To assess preliminary evidence of anti-neoplastic activity
Time frame: Feb 2011
To assess the pharmacokinetics of STA-9090 (ganetespib) when administered as a short-term intravenous infusion
Time frame: Feb 2011
To assess changes in biomarkers following study drug administration
Time frame: Feb 2011
To investigate drug exposure levels/plasma concentrations and correlations with efficacy and safety parameters
Time frame: Feb 2011
To assess the impact of variations in drug metabolizing enzymes (DME pharmacogenomics) on the pharmacokinetics of STA-9090 (ganetespib)
Time frame: Feb 2011
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