First Line Hepato Cellular Carcinoma (HCC)

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com. Inclusion Criteria: * Histologic or cytologic confirmed diagnosis of HCC. * Advanced HCC: disease not eligible for surgical and/or locoregional therapies OR progressive disease after surgical and/or locoregional therapies * Child-Pugh Class A * ECOG performance status 0-1 * Adequate hematologic, hepatic, and renal function Exclusion Criteria: * Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular targeted agents for HCC * History of active cardiac disease * Thrombotic or embolic events within the past 6 months (except HCC tumor thrombus) * Any other hemorrhage/bleeding event \>= CTCAE Grade 3 within 8 weeks except for esophageal or gastric varices * Inability to swallow tablets or untreated malabsorption syndrome