Neoadjuvant Cisplatin, Gemcitabine, Sunitinib Malate + Radical Cystectomy for TCC

Inclusion Criteria: * Histological proof of muscle-invasive transitional cell carcinoma of the bladder (stage II-III) with no evidence of metastatic disease (focal squamous and/or adenocarcinoma differentiation allowed, sarcomatoid and small-cell components not allowed). Patient with any degree of fixation of the pelvic sidewall are not eligible. * Must be willing to undergo a cystoscopy if tumor block is not available prior to registration for protocol therapy. * Eligible for radical cystectomy as per the attending urologist. * Prior radiation therapy to bone marrow is allowed to \< 25% of the marrow, and must be completed at least 6 months prior to registration for protocol therapy * Written informed consent and HIPAA authorization for release of personal health information. * Age \> 18 years at the time of consent. * Females of childbearing potential and males must be willing to use an effective method of contraception (hormonal or barrier method of birth control; abstinence) from the time consent is signed until 6 weeks after treatment discontinuation. * Females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for protocol therapy. Exclusion Criteria: * No prior radiotherapy to the pelvis. * No prior malignancy is allowed except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, Gleason\< grade 7 prostate cancers, or other cancer for which the patient has been disease-free for at least 5 years. * No treatment with any investigational agent within 30 days prior to registration for protocol therapy. * No cerebrovascular accident or transient ischemic attack within 6 months prior to registration for protocol therapy. * No evidence of pulmonary embolism within 6 months prior to registration for protocol therapy. * No uncontrolled hypertension (\>150/100 mm Hg despite optimal medical therapy). * No evidence of ongoing cardiac dysrhythmias of NCI CTCAE Version 3.0 grade 2. * No history of uncontrolled/untreated thyroid dysfunction. * No prolonged QTc interval (\> 450 msec) on pre-entry electrocardiogram obtained within 28 days prior to being registered on study. * Patients on warfarin (\>2mg) for thrombosis must be able and willing to switch to low molecular weight heparin prior to registration for protocol therapy. * No use of drugs having proarrhythmic potential (terfenadine, quinidine, procainamide, disopyramide, sotalol, probucol, bepridil, haloperidol, risperidone, indapamide and flecainide) within 7 days prior to registration for protocol therapy. * No use of CYP3A4 inhibitors (see section 5.3 for a list) within 7 days of registration for protocol therapy. * No use of CYP3A4 inducers (see section 5.3 for a list) within 14 days of registration for protocol therapy. * No use of amiodarone (CYP3A4 inhibitor) within 6 months of registration for protocol therapy. * Females must not be breastfeeding.