Effects of Gluten Digestion With ALV003

Inclusion Criteria: * Age 18-75 years * Well controlled Celiac Disease without flare in symptoms for the past 8 weeks * History of biopsy proven Celiac Disease * Able and willing to complete a symptom diary for 3 days prior and through 3 days post gluten challenge * Been on a gluten free diet for 8 weeks prior to study entry * Have normal celiac serology (anti- tTG level of \<20 units/mL) Exclusion Criteria: * Uncontrolled complications of celiac disease which in the opinion of the Investigator would impact their immune response, or pose an increased risk to the subject. (example: like type 1 diabetes or other autoimmune disease) * Pregnant or breast feeding women, subjects of childbearing potential to use two methods of contraception * Concomitant medications such as over the counter digestive enzymes, immunosuppressive therapies, anticoagulants, NSAIDs. Chronic medications for well-controlled chronic conditions are allowed. * Clinically significant abnormal lab values, as determined by the PI: * Untreated or active peptic ulcer disease, esophagitis, motility disorders or any gastrointestinal diseases. * Positive pregnancy test within 7 days prior to study drug administration * Known allergy or hypersensitivity to E.coli or E.coli derived proteins