Aromatase inhibitor therapy is in France the adjuvant reference treatment for postmenopausal women with early-stage breast cancer. This treatment induces bone loss and a higher risk of fractures. This study aimed to document the effect of bisphosphonate therapy in preventing bone loss and osteoporotic fractures in postmenopausal women with aromatase inhibitor treatment for breast cancer
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
35mg oral risedronate once per week for 24 months
Placebo 35 mg once a week for 24 months
Service de Rhumatology et de Pathologie Osseuse, Hôpital Edouard Herriot
Lyon, France
Evolution of the lumbar spine Bone Mineral Density after one year of treatment
Time frame: 1 year
Evolution of femoral BMD after one year of treatment
Time frame: 1 year
Evolution of lumbar spine and femoral BMD after two years of treatment
Time frame: 2 years
Evolution of bone resorption and formation markers
Time frame: 2 years
Proportion of fractures after two years of treatment
Time frame: 2 years
Evolution of estradiol levels
Time frame: 2 years
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