The purpose of the study is to determine if the concomitant administration of either ketoconazole or fluconazole with BMS-708163 will affect the PK of BMS-708163 and to assess safety and tolerability of BMS-708163
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Capsule, Oral, 50 mg, once, Day 1
(BMS-708163) - Capsule, Oral, 50 mg, daily, 1 day Day 12 (Ketoconazole) - Tablet, Oral, 400 mg, daily, 1 day
Tablet, Oral, 400 mg, daily, 16 days
Ppd Development, Lp
Austin, Texas, United States
PK profile of BMS-708163
Time frame: Within 14 days after dose
Safety and tolerability of BMS-708163 when administered alone and with either ketoconazole or fluconazole
Time frame: During the entire study period
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Tablet, Oral, 1 day 400 mg then 3 days 200 mg
(BMS-708163) - Capsule, Oral, 50 mg, daily, 1 day (Day 12) (Fluconazole) - Tablet, Oral, 200 mg, daily, 13 days