Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single Doses ofAZD2551

Inclusion Criteria: * Provision of signed, written and dated informed consent prior to any study specific procedures * Be willing to use barrier methods of contraception unless their partners are post-menopausal, surgically sterile or using accepted contraceptive methods * Have a body mass index between 18 and 30 kg/m2 inclusive and weight at least 50kg and no more than 100kg Exclusion Criteria: * Use of any prescribed or non-prescribed medication during the two weeks prior to the administration of study drug * History or presence of conditions known to interfere with the absorption, distribution, metabolism or excretion of drugs * Any impairment of kidney function or laboratory results for markers of kidney function that are outside the reference range and considered clinically significant * Underlying musculoskeletal symptoms of unknown origin, subjects with shoulder girdle musculoskeletal symptoms or Dupuytrens syndrome