Goal Directed Fluid Therapy

Medical University of Vienna90 enrolled

Overview

Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.

To our knowledge no data are available on the effect of goal-directed fluid therapy on hemodynamics in lean patients and obese patients, respectively. Consequently, we want to compare lean patients (BMI \<25) vs. obese patients (BMI \>25) in regard of their respective needs for intraoperative fluid therapy, and the impact of the goal-directed fluid regimen on tissue oxygenation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Goal Directed Fluid Therapy

Interventions

fluidotherapy with ringer-lactateDRUG

a bolus of 250ml ringer-lactate is administered, if there is fluid demand monitored by the Esophageal Doppler

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * female patients (18 - 80 years) undergoing elective gynecological open surgery (hysterectomy, ovarian cysts and tumors, myomectomy, endometriosis) Exclusion Criteria: * cardiac insufficiency (EF\< 35%) * renal insufficiency (creatinin clearance \<30ml/min, dialysis) * insulin dependant diabetes mellitus * coagulopathy * NYHA IV * infection * sepsis * history of suspect malignant hyperthermia * porphyria

Locations (1)

Medical University Vienna

Vienna, Austria

Outcomes

Primary Outcomes

different hemodynamic fluid responses in the different groups

Time frame: every 10 minutes during surgery

Secondary Outcomes

Subcutaneous oxygen tension (PsqO2)

Time frame: every 10 minutes during surgery and 2 hours postoperatively

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.