The Effect of Single Doses of the Motilin Receptor Agonist GSK962040 in Type I Diabetic Patients With Gastroparesis

Inclusion Criteria: * Controlled Type 1 Diabetes Mellitus (glucose \< 250 mg/dL) with onset \< 30 years of age. * Male or female between 18 and 70 years of age, inclusive. * Patient has documented diagnosis of moderate to severe gastroparesis (\> 30% at 2 h as determined by scintigraphy; or t1/2b \> 109 min as determined by 13C-octanoic acid breath test). All of the following apply: * Confirmed delayed gastric emptying (properly conducted gastric emptying assessments within last 6 months acceptable) AND a minimum 3 month history of relevant symptoms for gastroparesis (e.g., chronic postprandial fullness, postprandial nausea, vomiting) * A female patient is eligible to participate if she is of: * Non-childbearing potential * Child-bearing potential and agrees to use contraception for at least 4 days following the last dose of study medication. * Male patients must agree to use contraception from the time of the first dose of study medication through at least 4 days after the last dose of study medication. * Body weight ≤110 kg and BMI \< 32.0 kg/m2 (inclusive). * Patient has never had a gastrectomy, nor major gastric surgical procedure or any evidence of bowel obstruction within the previous 12 months * Dosage of any concomitant medications has been stable for at least 3 weeks, except for routine adjustments in daily insulin treatments * HbA1c level is ≤ 10.0% * Calculated creatinine clearance \> or equal to 50 ml/min * QTcB or QTcF \< 450 msec or QTc\<480msec in patients with Bundle Branch Block based on single or average QTc value of triplicate values obtained over a brief recording period. * AST, ALT, alkaline phosphatase and bilirubin ≤ 1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%) * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. Exclusion Criteria: * Patient has acute severe gastroenteritis * Patient has a gastric pacemaker * Patient is on chronic parenteral feeding * Patient has daily persistent severe vomiting * Patient has pronounced dehydration * Patient has had clinical diabetic ketoacidosis in last 4 weeks * Patient has a history of eating disorders (anorexia nervosa, binge eating, bulimia) * Use of medications potentially influencing upper gastrointestinal motility or appetite within one week of the study (e.g., prokinetic drugs, macrolide antibiotics (erythromycin)) * Patient is taking opiates. * Use of prohibited medications listed in Section 9.2 within the restricted timeframe relative to the first dose of study medication. * History or presence of clinically significant gastro-intestinal, hepatic or renal disease or other condition known to interfere with the absorption, distribution, metabolism or excretion of drugs. * Presence of thyroid dysfunction (NOTE: patients with abnormal TSH at screening/baseline are not eligible. Patients with a history of hypothyroidism on a stable dose of thyroid replacement therapy are eligible to participate in the study). * The patient has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation. * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Pregnant females as determined by positive serum or urine hCG test (from the first urine of the day) at screening or prior to dosing. * Lactating or pregnant females. * Unwillingness or inability to follow the procedures outlined in the protocol. * Patients deemed unable to comply with the procedures outlined in the protocol may be excluded at the Investigator's discretion. * For male volunteers: An unwillingness of the male patient to comply with the contraception requirements listed in Section 8.1, from the time of the first dose of study medication until at least 4 days following administration of the last dose of study medication. * A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening.