To evaluate the persistence of bactericidal antibodies in adolescents and adults who received one dose of Menactra® vaccine approximately four to eight years earlier
Subjects who received one dose of Menactra® or Menomune® in study MTA04, MTA12, MTA19 (NCT00777790), or MTA21 (NCT00777257) will be eligible for enrollment in trial this study. All eligible subjects will provide a blood sample at Visit 1, after which their participation in the study will be terminated. An age-matched meningococcal-vaccine naïve control group will be recruited to provide a blood sample for baseline antibody level evaluation. No vaccine will be administered in this study.
Study Type
OBSERVATIONAL
Enrollment
763
Unnamed facility
Little Rock, Arkansas, United States
Unnamed facility
Fountain Valley, California, United States
Percentage of Participants With Serum Bactericidal Antibody Titers for Meningococcal Serogroups A, C, Y, and W-135 at ≥ 8 and ≥ 128 at Enrollment
Time frame: Day 0
Geometric Mean Titers of Serum Bactericidal Antibody Assay Using Baby Rabbit Complement (SBA-BR) at Enrollment
Time frame: Day 0
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Unnamed facility
Marietta, Georgia, United States
Unnamed facility
Martinez, Georgia, United States
Unnamed facility
Woodstock, Georgia, United States
Unnamed facility
Bardstown, Kentucky, United States
Unnamed facility
Omaha, Nebraska, United States
Unnamed facility
Austintown, Ohio, United States
Unnamed facility
Cleveland, Ohio, United States
Unnamed facility
Erie, Pennsylvania, United States
...and 10 more locations