Circulating microRNAs as Biomarkers of Sepsis

Changhai Hospital100 enrolled

Overview

MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sepsis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients who develop sepsis and undergo abdominal surgery * patients who develop SIRS after cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * patients with a primary diagnosis of acute pancreatitis * patients with cirrhosis or renal dysfunction * patients with dyscrasia * patients with autoimmunity diseases * patients with severe cardiac and pulmonary diseases * patients with hematological diseases * patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass

Locations (1)

Changhai Hospital, Second Military Medical University

Shanghai, China

Outcomes

Primary Outcomes

Relative amount of circulating microRNAs

Time frame: On the second day of diagnosis of sepsis in ICU

Secondary Outcomes

Serum levels of CRP and IL-6

Time frame: On the second day of diagnosing sepsis

Apache II score and death

Time frame: On the second day of diagnosis of sepsis

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.