Immunohistochemical Expression Patterns of microRNA Processing Enzyme Dicer in Cutaneous Malignant Melanoma, Benign and Dysplastic Melanocytic Naevi

Ruhr University of Bochum30 enrolled

Overview

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the researchers investigate the immunohistochemical distribution of Dicer in benign and dysplastic melanocytic naevi as well as in cutaneous malignant melanoma compared to intraindividual healthy control.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Naevi Malignant Melanoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with benign melanocytic naevi, dysplastic melanocytic naevi and cutaneous malignant melanoma. Exclusion Criteria: * Patients under 18 years of age * Patients with other forms of cancer in previous medical history * Pregnancy

Locations (1)

Department of Dermatology and Allergology, Ruhr-University Bochum