Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

Corporacion Parc Tauli68 enrolled

Overview

The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH). Also, some of the mechanisms mediating SAS and RAH (systemic inflammation, oxidative stress, sympathetic hyperactivity) will be analyzed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Obstructive Sleep Apnea Refractory Arterial Hypertension

Interventions

CPAPDEVICE

continuous positive airways pressure

ControlDEVICE

Patients are 3 months without any change in their treatment, and are in the waiting list to come into the CPAP procedure after that time

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * refractory arterial hypertension and sleep apnea with apnea-hypopnea index over 15 Exclusion Criteria: * excessive sleepiness * professional drivers * secondary arterial hypertension

Locations (1)

Corporacio Parc Tauli

Sabadell, Barcelona, Spain

Outcomes

Primary Outcomes

24 hours blood pressure monitoring

Time frame: basal and after three months of CPAP treatment

Secondary Outcomes

oxidative stress and inflammatory mediators

Time frame: basal and after three months of CPAP treatment

Data from ClinicalTrials.gov

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