Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients

Inclusion Criteria: * Histopathologically or cytologically proven diagnostic of Primary CNS lymphoma * All histological types of non-Hodgkin's lymphoma, except MALT * Age \> 18 and \< 60 ans. * Negative for HIV, HCV and HBV * Written informed consent - Exclusion Criteria: * Age \< 18 or \> 60 ans * Isolated intra-ocular lymphoma * Previous history of indolent lymphoma * Previous chemotherapy or radiotherapy for PCNSL * Isolated CNS relapse of systemic NHL * Previous history of cancer in the last 5 years, except basocellular carcinoma and non invasive cervix cancer * Renal insufficiency or creatinin clearance \< 60 ml/min * Liver enzymes \> 3N. * Platelets \< 100 000/mm3 or neutrophils \< 1500/mm3) * Previous history of organ transplantation or other cause of severe immunodeficiency * Pregnancy or active sexual women with no contraception * Unable to follow the protocol for any reason