Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

Aarhus University Hospital12 enrolled

Overview

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal. Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Obesity Postprandial Lipemia Atherosclerosis Inflammation Postprandial Incretins

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \> 30 kg/m2 \& \< 45 kg/m2 Exclusion Criteria: * Diabetes * Lipid lowering drugs * Liver-, Kidney- and/or Heart Disease * Serious Hypertension (160/110)

Outcomes

Primary Outcomes

Triglyceride

Time frame: 0h- 2h- 4h- 6h- 8h postprandial

Secondary Outcomes

Incretins

Time frame: 0h -1h -2h -4h -6h -8h Postprandial

Inflammatory markers

Time frame: 0h- 1h- 2h- 4h- 6h- 8h postprandial