Biological Factors Predicting Response to Chemotherapy in Advanced Non Small Cell Lung Cancer

Inclusion Criteria: * Histological diagnosis of non-small-cell lung cancer (NSCLC) * Obtention of a biopsy of the tumour according to the procedure defined in the protocol * NSCLC of any stage to be treated by standard conventional first-line chemotherapy, as defined in the ELCWP guidelines (www.elcwp.org) * Presence of at least one assessable lesion * Availability for participating in the detailed follow-up of the protocol * Signed informed consent. * Age above 18 years Exclusion Criteria: * Patient who was previously treated with chemotherapy for NSCLC or who has any contra-indication precluding the administration of conventional chemotherapy for NSCLC * NSCLC treated by exclusive surgery or radiotherapy * A history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or of the bladder or cured malignant tumour (more than 5-year disease free interval)