Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
156
3.3 mL normal saline
lidocaine 50 mg plus propofol 50 mg intravenous (iv)
lidocaine 50 mg iv under tourniquet-control
Benaroya Research Institute
Seattle, Washington, United States
Verbal Pain Score
11 point verbal pain score (VPS) 0=no pain; 10=worst imaginable pain
Time frame: Immediately after injection of study drug. One time assessment.
Complete Alleviation of Injection Pain
Total subjects within the arm versus those subjects who had no pain with injection (VPS=0)
Time frame: Immediately after injection of study drug. One time assessment
Satisfaction With Anesthetic Technique
Were you satisfied with the anesthetic technique? Yes/No
Time frame: Prior to discharge. One time assessment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.