An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice

AstraZeneca1,500 enrolled

Overview

The present study is a retrospective cohort study on patients who suffered a nosocomial infection in major hospitals in Vietnam. Data relating to patient demography include age, gender; medical history; APACHE II score; background conditions, infection details and antimicrobial therapy; and all-caused mortality, time of hospitalization and intensive care. The investigators hypothesis is that antimicrobial treatment inappropriate is highly dependent on incidence of antibiotic resistant pathogens, nonfermentative Gram-negative bacilli and ESBL-producing enterobacteriaceae spp. Variables are demographic characteristics, background conditions, immunosuppressive therapy, antimicrobial susceptibility and inappropriate treatment is explored as possible predictors of mortality.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Nosocomial Infection

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patient was diagnosed as nosocomial infection defined according to criteria established by the US CDC. The diagnosis criteria for ventilator-associated pneumonia are modified from those established by the American College of Chest Physicians. * Patient received empiric antimicrobial therapy within 24 hour from onset of infection and had antimicrobial susceptibility. Exclusion Criteria: * A patient was in part of a controlled clinical trial for the current infection episode. * Patients with suspected infections by virus or fungus or tuberculosis will be excluded.

Locations (2)

Outcomes

Primary Outcomes

The number and percentage of subjects with nosocomial infection received appropriate antimicrobial treatment

Time frame: 30 days as from onset of nosocomial infection

Secondary Outcomes

The number and percentage of patients with nosocomial infections received de-escalation therapy

Time frame: 30 days as from onset of nosocomial infection

The number and percentage of hospital mortality, the number of days for hospitalization, intensive care among groups of patients who received appropriate or inappropriate antimicrobial treatments

Time frame: 30 days as from onset of nosocomial infection

The determinants for inappropriate antimicrobial treatment and mortality.

Time frame: 30 days as from onset of nosocomial infection