Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

University of Erlangen-Nürnberg Medical School50 enrolled

Overview

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Primary Hypertension

Interventions

spironolactoneDRUG

25mg per oral once daily

placeboDRUG

placebo

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis hypertension (BP higher than 139/89) Exclusion Criteria: * Antihypertensive pretreatment * Contraindications against spironolactone * Being unable to understand or comply with study procedures

Locations (1)

University Erlangen-Nürnberg, Nephrology and Hypertension

Erlangen, Germany

Outcomes

Primary Outcomes

left ventricular mass

Time frame: 8 weeks

Data from ClinicalTrials.gov

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