Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation

Maastricht University Medical Center24 enrolled

Overview

The body of evidence regarding the health benefits of green tea has grown considerably during the last decade and includes antioxidant properties, anti- cancer, anti-obesity and anti-diabetes effects. There has been evidence that green tea extract favorably affect body weight and body fat and has positive effects on blood glucose control Aim of this study is to investigate the short term effect (3-day)of TEAVIGO (high in the catechin EGCG) on postprandial fat oxidation during different phases of the postprandial period in overweight subjects. Secondly, in a subset of volunteers changes in lipolysis and glucose metabolism will be studied in skeletal muscle and adipose tissue.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Obesity Type 2 Diabetes Mellitus

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 20 and 50 y * BMI 25.0-29.9 kg/m2 * Normal fasting glucose \<6.1 mmol/L * Blood pressure (systolic blood pressure 100-150 mmHg, diastolic blood pressure 60-90 mmHg) * Weight stable in last 3 months (±2 kg) Exclusion Criteria: * pregnant, lactating or (post)menopausal women * regular smokers * people with intensive fitness training eg athletes * habitual consumption of green or black tea (more than 1 or 2 cups a day, respectively) * not more than 300 mg/day caffeine consumption

Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes