A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

University of Aarhus60 enrolled

Overview

The purpose of this study is to determine wether ketorolac is effective in the treatment of postoperative pain after total knee arthroplasty

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

30 mg (1 ml) infiltration combined with Intraarticular bolus injection of 120 mg (4 ml) ketorolac

1 ml infiltration 4 ml intraarticular bolus injection of placebo

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Total knee arthroplasty * Age \> 18 * Tolerance for study drugs * Written informed consent Exclusion Criteria: \-

Aarhus University

Aarhus, Denmark

Morphine Consumption

Consumption of intravenous (i.v.) patient-controlled analgesia (PCA) morphine during the first forty-eight hours after surgery

Time frame: 48 hours after surgery

Time to First i.v. Patient Controlled Analgesia (PCA) Morphine Request

Time frame: within 48 hours after surgery

Pain Intensity Scores During Walking

Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)

Time frame: 6-24 hours postoperatively

Home Readiness

Ability to meet discharge criteria (home readiness)

Time frame: time to fulfilment of discharge criteria

Length of Hospital Stay

Time frame: From the day of surgery until discharge

Pain Intensity During Daily Activity

Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)

Time frame: 16 weeks after surgery

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