An Investigation on the Effect of Age and BMI on the Pharmacokinetics of Transdermal Granisetron

Inclusion Criteria: \-- Healthy male or female subjects: Part I * Aged ≥ 65 years at screening * Control group: aged ≥ 18 to 45 years at screening Part II -- Aged between 18 and 60 years, inclusive, at screening Part I \-- BMI between 20.0 and 29.9 kg/m², inclusive Part II * Underweight (BMI \< 18.5 kg/m²) or obese (BMI between 30.0 and 39.9 kg/m², inclusive) * Control group: BMI between 20.0 and 24.9 kg/m², inclusive Exclusion Criteria: * Current or previous disease, disorder, allergy or condition that could affect study conduct or laboratory assessments, or that presents undue risk from study medication or procedures. * Physical examination or screening investigation result that indicates subject is unfit for study. * Scarring on upper arms. * Positive virology, urine drugs of abuse or pregnancy test result (female subjects of childbearing potential only). * Recent use of prescribed or over-the-counter medication. * Received an investigational drug within 3 months (90 days) prior to patch application. * Loss of ≥ 400 mL of blood (e.g. been a blood donor) within the previous 3 months. * Average weekly alcohol consumption \> 21 units (males) or 14 units (females), or habitually smokes ≥ 5 cigarettes or equivalent tobacco per day within the 6 months before patch application. * Lactating female subjects and female subjects of childbearing potential not willing to use an acceptable form of contraception during and for 90 days after the study. * Employee of the investigator or study centre, with direct involvement in the proposed study or other studies under the direction of that investigator or study centre, as well as family members of the employees or the investigator.