Comparison of Nadifloxacin Cream Alone and With Benzoyl Peroxide Solution in the Treatment of Acne

Marmara University90 enrolled

Overview

The purpose of this study is to determine whether using of nadifloxacine 1% cream and benzoyl peroxide 5% solution together is more effective than using nadifloxacine alone in the treatment of mild to moderate facial acne.

Nadifloxacin; a new topical antibiotic for the treatment of acne has recently been marketed in our country. Only a few studies on its use and effectiviness could be found in the literature. Nadifloxacin may be an alternative to other topical antibiotics and benzoyl peroxide or its use along with benzoyl peroxide may be more effective and rational to prevent possible future resistance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Acne Vulgaris

Interventions

benzoyl peroxideDRUG

benzoyl peroxide %5 solution once dailly

nadifloxacineDRUG

Nadifloxacine 1% cream twice dailly

Eligibility

Sex: ALLMin age: 14 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of mild to moderate facial acne vulgaris * Must have at least 10 inflammatory and/or non-inflammatory and no more than 3 nodulocystic acne lesions Exclusion Criteria: * Nodulocystic acne lesions more than 3 and pure comedonal acne * Additional truncal acne needs systemic therapy * Usage of topical treatments for acne in last 2 weeks, systemic antibiotic in last 4 weeks, systemic isotretinoin in last 6 months * Application of chemical peels and laser in last 4 weeks * Usage of hormones in last 3 months * Clinical signs of hyperandrogenism in females * Pregrancy and lactation * Hypersensitivity to interventions * Additional facial skin diseases (eg. atopic and seborreic dermatitis) * Photosensitive disorders and usage of drugs which can trigger Photosensitive conditions

Locations (1)

Marmara University school of medicine

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Number of patients whom inflammatory lesions were decreased %50 or more

Time frame: two months

Secondary Outcomes

the number of patients whom were observed side effects

Time frame: two months

Data from ClinicalTrials.gov

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