Study of the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults

Inclusion Criteria: * Plasma HIV-1 RNA levels ≥ 5,000 copies/mL * No prior use of any approved or experimental anti-HIV drug * Normal electrocardiogram (ECG) * Adequate renal function: estimated glomerular filtration rate ≥ 80 mL/min according to the Cockcroft-Gault formula * Hepatic transaminases ≤ 2.5 x upper limit of normal (ULN) * Total bilirubin ≤ 1.5 mg/dL, or normal direct bilirubin * Adequate hematologic function * Cluster determinant 4 (CD4) cell count \> 50 cells/µL * Serum amylase ≤ 1.5 x ULN * Normal thyroid-stimulating hormone * Negative serum pregnancy test (for females of childbearing potential only) * Males and females of childbearing potential must agree to utilize highly effective contraception methods from screening throughout the duration of study treatment and for 12 weeks following the last dose of study drugs * Life expectancy ≥ 1 year * Ability to understand and sign a written informed consent form Exclusion Criteria: * New acquired immunodeficiency syndrome (AIDS)-defining condition diagnosed within the 30 days prior to screening * Documented drug resistance to nucleoside reverse transcriptase inhibitors or nonnucleoside reverse transcriptase inhibitors or primary protease inhibitor resistance mutation(s) * Hepatitis B surface antigen positive * Hepatitis C antibody positive * Participants experiencing cirrhosis * Participants experiencing ascites * Participants experiencing encephalopathy * Females who are breastfeeding * Positive serum pregnancy test (for females of childbearing potential) * Vaccinated within 90 days of study dosing * History or family history of Long QT Syndrome or family history of sudden cardiac death or unexplained death in an otherwise healthy individual under the age of 30 * Presence or history of cardiovascular disease, cardiomyopathy, and/or cardiac conduction abnormalities * Prolonged QTcF interval at screening * PR interval ≥ 200 msec or ≤ 120 msec on ECG at screening * QRS ≥ 120 msec on ECG at screening * Implanted defibrillator or pacemaker * Participants receiving ongoing therapy with any disallowed medications * Current alcohol or substance use judged to potentially interfere with participant study compliance * History of or ongoing malignancy (including untreated carcinoma in situ) other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, noninvasive cutaneous squamous carcinoma * Active, serious infections (other than HIV-1 infection) requiring parenteral antibiotic or antifungal therapy within 30 days prior to baseline * Participation in any other clinical trial without prior approval * Medications contraindicated for use with EFV, EVG, COBI, FTC, or TDF * Any known allergies to the excipients of Atripla or Stribild tablets * Any other clinical condition or prior therapy that would make the participant unsuitable for the study or unable to comply with the dosing requirements