There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging. Recent evidence suggest that testosterone or DHEA may improve ovarian response in poor prognosis patients by increasing intraovarian androgen concentration. A physiological way to induce androgen synthesis within the ovary is to stimulate theca cells androgen production by hCG stimulation. By doing this in the previous cycle we might expect a better response to COH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
200 IU, sc, every 5 days, 4 doses
diluent, every 5 days, s.c., 4 doses
IVI-Madrid
Madrid, Spain
pregnancy rate
Time frame: 2 weeks after intervention
number of oocytes retrieved
Time frame: 2 weeks after intervention
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